Cat#:RP-448AC;Product Name:Biotinylated Recombinant Human EGFRvIII Protein(Avi Tag);Synonym:EGFR,ERBB,ERBB1,HER1,PIG61,mENA;Background:Gene ID: 1956. EGFR, the full name is epidermal growth factor receptor. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jun 2016];Description:Biotinylated recombinant Human EGFRvIII protein is produced in HEK293 cells.;Source:HEK293;Predicted N Terminal:Leu 25;Purity:Greater than 95% as determined by SDS-PAGE.;Endotoxin:< 1.0 EU per μg of Biotinylated Recombinant Human EGFRvIII protein by the LAL method.;Formulation:Biotinylated Recombinant Human EGFRvIII protein was lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.Contact us for customized product form or formulation.;Stability:Biotinylated Recombinant Human EGFRvIII protein was stable up to 1 year from date of receipt at -70℃;Host Species:Human;Storage:Store Biotinylated Recombinant Human EGFRvIII protein under sterile conditions at -20℃ to -80℃. It is recommended that the recombinant protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.;Usage:For Lab Research Use Only;References:Prognostic implication of EGFR gene mutations and histological classification in patients with resected stage I lung adenocarcinoma. Lin CY, et al. PLoS One, 2017. PMID 29065153;