Cat#:MCP1-003RPH;Product Name:Recombinant Human MCP1 / CCL2 Protein(His Tag);Synonym:CCL2; C-C motif chemokine ligand 2; HC11; MCAF; MCP1; MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30;Background:Gene ID: 6347. CCL2, the full name is C-C motif chemokine ligand 2. This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. [provided by RefSeq, Jul 2013];Description:A DNA sequence encoding the human CCL2 (NP_002973.1) was expressed in yeast. The MCP1 recombinant human protein was fused with a His tag at the C-terminus.;Source:Yeast;Predicted N Terminal:Gln 24;AA Sequence:Gln24-Thr99;Molecular Characterization:The recombinant human CCL2 protein consists 86 amino acids and predicts a molecular mass of 10.1 kDa.;Purity:Greater than 95% by SDS-PAGE;Formulation:The recombinant human MCP1 protein was lyophilized from sterile PBS, pH 7.4.;Stability:Recombinant human MCP-1 Proteins are stable for up to 1 year from date of receipt at -70℃;Host Species:Human;Storage:Store the MCP-1 recombinant protein under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.;Usage:For Lab Research Use Only;References:Monocyte chemoattractant protein-1 (MCP-1)-2518 A/G polymorphism and lupus nephritis risk: A PRISMA-compliant meta-analysis. Sang GY, et al. Medicine (Baltimore), 2017 Dec. PMID 29390552;