Cat#:STAT3-001RPH;Product Name:Recombinant Human STAT3 Protein(GST Tag);Synonym:STAT3; APRF; HIES; ADMIO; ADMIO1; signal transducer and activator of transcription 3;Background:The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2015];Description:Recombinant human STAT3 protein(full-length) was produced by baculovirus in Sf9 insect cells. The STAT3 recombinant protein was fused with a GST tag at N-terminal. ;Source:Sf9 insect cells;AA Sequence:Full length;Molecular Characterization:120 kDa ;Purity:Greater than 90% by densitometry;Bioactivity:Active;Formulation:Liquid Solution;Stability:Recombinant human STAT3 proteins are stable for up to 1 year from date of receipt at -70℃;Host Species:Human;Application:Kinase Assay, WB, ELISA, Antibody Production;Concentration:0.2ug/ul;Storage:Store the human STAT3 protein at -70℃. For optimal storage, please aliquot target into smaller quantities after centrifugation and store at the recommended temperature. Avoid repeated freeze/thaw cycles. ;Usage:For Lab Research Use Only;Supplied in:50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. ;