Cat#:RP-RANKL-01C;Product Name:Recombinant Cynomolgus RANKL / OPGL / TNFSF11 Protein (Fc Tag);Synonym:CD254,hRANKL2,ODF,OPGL,OPTB2,RANKL,sOdf,TRANCE;Description:A DNA sequence encoding the cynomolgus RANKL/TNFSF11 (G7PW41) (Gly136-Asp317) was expressed with the Fc region of human IgG1 at the N-terminus. Recombinant cynomolgus RANKL protein was produced in Human cells. The RANKL cynomolgus recombinant protein was purified by our unique chromatographic techniques.;Source:Human Cells;Predicted N Terminal:Glu;Molecular Characterization:The recombinant cynomolgus RANKL/TNFSF11 comprises 442 amino acids and has a calculated molecular mass of 48.9 KDa. The apparent molecular mass of the protein is approximately 55 KDa in SDS-PAGE.;Purity:Greater than 85 % as determined by SDS-PAGE;Endotoxin:< 1.0 EU per μg of the cynomolgus RANKL protein as determined by the LAL method;Bioactivity:The bioactivity of RANKL protein was determined by measuring the ability of RANKL to induce TRAP activity in Raw 264.7 cells.;Formulation:Recombinant Cynomolgus RANKL protein was lyophilized from sterile PBS, pH 7.4;Stability:Recombinant Cynomolgus RANKL Proteins are stable for up to 1 year from date of receipt at -70℃;Storage:Lyophilized recombinant cynomolgus RANKL protein is stable at 4-8℃ for 2-4 weeks. Upon reconstitution, Recombinant cynomolgus RANKL protein should be stored at 4°C between 2-7 days and for future use below -20°C. Avoid freeze-thaw cycles.;References:1. Nakashima T, et al. (2003) RANKL and RANK as novel therapeutic targets for arthritis. Curr Opin Rheumatol. 15(3): 280-7. 2.Leibbrandt A, et al. (2008) RANK/RANKL: regulators of immune responses and bone physiology. Ann N Y Acad Sci. 1143: 123-50. ;