Cat#:KAT2B-RP02E;Product Name:Active Recombinant Human KAT2B Protein;Synonym:KAT2B; lysine acetyltransferase 2B; CAF; PCAF; P/CAF; histone acetyltransferase KAT2B; CREBBP-associated factor; K(lysine) acetyltransferase 2B; histone acetylase PCAF;Background:KAT2B, the full name is lysine acetyltransferase 2B. The Gene ID is 8850. CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008];Description:Recombinant human KAT2B protein, produced in Sf9 insect cells was fused with a GST tag at the N-terminal.The AA sequence is from 431 to the end. KAT2B recombinant protein was purified using our unique purification techniques. ;Source:Sf9, Insect Cells.;AA Sequence:aa 431-end;Molecular Characterization:70 kDa ;Purity:Greater than 95% by SDS-PAGE;Bioactivity:32 nmol/min/mg ;Formulation:Liquid Solution;Stability:Recombinant human KAT2B proteins are stable for up to 1 year from date of receipt at -70℃;Host Species:Human;Application:Acetyltransferase Assay ;Concentration:0.1μg/μl;Storage Buffer:50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. ;Storage:The recombiant human KAT2B protein is shipped using dry ice. Store recombinant human KAT2B enzyme at –70 degree. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Please avoid repeated freeze/thaw cycles.;Usage:For Lab Research Use Only;References:Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. Dorr, A., Kiermer, V., Pedal, A., Rackwitz, H.R., Henklein, P., Schubert, U., Zhou, M.M., Verdin, E., Ott, M. EMBO J. (2002);