Cat#:KAT2A-001AH;Product Name:Active Recombinant Human KAT2A / GCN5 Protein ;Synonym:GCN5; Histone acetyltransferase KAT2A; hGCN5; GCN5L2; PCAF-b; lysine acetyltransferase 2A; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; General control of amino acid synthesis, yeast, homolog-like 2; K(lysine) acetyltransferase 2A; STAF97;Background:Gene ID: 2648. KAT2A, the full name is lysine acetyltransferase 2A. KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]. HIV-1 NL4-3 replication requires KAT2A as replication is inhibited when KAT2A is deleted through CRISPR/Cas9 genome editing. Knockdown of K(lysine) acetyltransferase 2A (KAT2A; GCN5L2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells.;Description:Active KAT2A human recombinant(From aa 323-end) was expressed by baculovirus in Sf9 insect cells. The GCN5 protein was fused with an GST tag at N-terminal.;Source:Sf9 insect cells;AA Sequence:aa 323-end;Molecular Characterization:82 kDa ;Purity:Greater than 85% by densitometry;Bioactivity:The activity of KAT2A protein was determined to be 22nmol/min/mg.;Formulation:Liquid Solution;Stability:Recombinant Human KAT2A Proteins are stable for up to 1 year from date of receipt at -70℃;Host Species:Human;Application:Acetyltransferase Assay ;Concentration:0.1ug/ul;Storage Buffer:The human KAT2A protein was supplied in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.;Storage:The recombiant human GCN5 protein is shipped using dry ice. Store recombinant human KAT2A enzyme at –70 degree. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Please avoid repeated freeze/thaw cycles. ;Usage:For Research Use Only!;References:Quantitating the specificity and selectivity of Gcn5-mediated acetylation of histone H3. Kuo YM, et al. PLoS One, 2013. PMID 23437046;